MRI Measurement Of Liver Iron Concentration

FerriScan is internationally recognised as the gold standard in liver iron concentration (LIC) measurement and is included in a number of international Standards of Care.

FerriScan is a system for quantifying liver iron concentration (LIC) from specially acquired MRI images.   The images used are standardised R2-MRI images (acquired using the ‘FerriScan protocol’) and proprietary internationally regulatory-cleared software is used to quantify liver iron concentration (LIC).  Analysis is performed under stringent, quality controlled conditions (ISO 13485:2016 certified) in a central core laboratory by a team of highly trained engineers and physicists.  FerriScan analysis has the highest sensitivity and specificity over the range of liver iron concentrations of any MRI-based method of LIC measurement, producing results that are reliable and reproducible over time and across different makes and models of MRI scanner. To date, FerriScan has been used to non-invasively measure LICs in over 50,000 patients.

FerriScan has international regulatory clearances.  It was granted clearance by the FDA (US) for the quantification of LIC in 2005. In January 2013 FerriScan gained an additional clearance from the FDA as a companion diagnostic to aid in the identification and monitoring of non-transfusion-dependent thalassemia patients receiving therapy with deferasirox.  FerriScan also has clearances form the TGA (Australia) and CE Mark (Europe).

The FerriScan process uses patented R2-MRI imaging technology. Once MRI images have been acquired, these images are securely transmitted via webportal to Resonance Health. The Resonance Health weportals are HIPAA, GDPR, and Privacy Act compliant.  Once analysis is complete, results are returned via webportal.  For information on data transfer processes and security please contact [email protected].  


The FerriScan Report

FerriScan was originally calibrated against liver biopsy in patients with various iron overload conditions.

An increasing number of patient treatment guidelines for thalassaemia, sickle cell disease, myelodysplastic syndrome and haemochromatosis recommend using FerriScan to quantitatively measure liver iron concentration. 

For a compiled list of treatment guidelines involving R2 MRI (FerriScan), please click here.

Key FerriScan Features

Why Use FerriScan R2-MRI to Measure Liver Iron Concentration?

FerriScan is quick, easy and painless, with an MRI scan time of approximately 7-9 minutes.   FerriScan is a free-breathing technique (no breath-hold required), and FerriScan does not require any contrast agents.  

FerriScan provides a more accurate and reliable measure of LIC at any point in time than that provided by serum ferritin and patients need no longer undergo the painful, time consuming process of liver biopsy.

Unlike liver biopsy, which provides an analysis of LIC in only one small area, FerriScan analyses a cross-section of the liver. This area is typically thousands of times larger than biopsy, hence significantly reducing the biopsy sampling error.

The Liver iron Concentration (LIC) measurement can be used by clinicians to monitor iron loading and adjust treatment regimens accordingly.

FerriScan is being used by clinicians in over 45 countries worldwide to aid their diagnosis, management and monitoring of iron overload.

FerriScan is a solution with proven value in improving the health outcomes of patients suffering from diseases such as thalassaemia, sickle cell disease, haemochromatosis and myelodysplastic syndrome.


Advantages of FerriScan over serum ferritin (SF)

Advantages of FerriScan over liver biopsy

Advantages of FerriScan over Liver T2* (MRI)

Graph shows various Liver T2* conversions to LIC.

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