Automated MRI Measurement Of Liver Iron Concentration
FerriSmart is an automated system for measuring liver iron concentration (LIC). FerriSmart uses a specially trained convolutional neural network (artifical intelligence – machine learning) to analyse R2-MRI images to quantify the patient’s LIC. These images, acquirable on most makes and models of 1.5 Tesla MRI machines, are obtained through a unique and standardised scanning sequence to ensure results are accurate, reliable, and reproducible over time and between hospitals and the various makes and models of MRI scanners.
In addition to FerriScan, FerriSmart is the only FDA approved MR companion diagnostic for use with deferasirox. Due to the quality-controlled, standardised nature of the test, a patient may have a FerriSmart at any FerriSmart-verified MRI centre, anywhere in the world, and receive reproducible, and reliable results.
Once acquired, these images are uploaded to the FerriSmart neural network via web portal or through verified channel partners. FerriSmart delivers analysis results virtually instantaneously, with a report delivered directly back to the clinician and patient in real-time. FerriSmart offers a fully integrated and automated analysis service.
The reliability of FerriScan and FerriSmart provide clinicians with data required to optimize patient treatment based on their actual level of liver iron overload.
Key FerriSmart Features
Advantages of FerriSmart over serum ferritin (SF)
Advantages of FerriSmart over liver biopsy
Advantages of FerriSmart over Liver T2* (MRI)
Graph shows various Liver T2* conversions to LIC.
FerriSmart via Resonance Health
FerriSmart is a stand-alone software application that automatically analyses MRI (DICOM) images that are uploaded via the FerriSmart web portal. These images, acquirable on most makes and models of 1.5 Tesla MRI machines, are obtained through a unique and standardised scanning sequence to ensure results are accurate, reliable, and reproducible over time and between hospitals and the various makes and models of MRI scanners.
The entire FerriSmart analysis process is completely automated. The FerriSmart technology will initially inspect all images to ensure that they have been acquired with the correct protocol. If errors are detected in the method of data acquisition, FerriSmart will not analyse the data but will indicate the corrective steps that need to be taken to acquire compliant images. If no data acquisition errors are detected, FerriSmart automatically chooses the optimum slice for analysis, measures the mean liver iron concentration in that slice, and produces a liver iron concentration report that can be saved as a PDF file or printed out for patient records. Uploading and analysis of data typically takes about 30 seconds.
Due to the quality-controlled, standardized nature of the test, a patient may have a FerriSmart at any FerriSmart-verified MRI centre, anywhere in the world.
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“Serum ferritin generally correlates with total body iron stores. However, predictive value of serum ferritin is quite poor and patients with identical SF can have highly variable body iron burden. Further, change in liver iron may not be predicted accurately enough from ferritin measurements. Over reliance to serum ferritin trends may lead to inappropriate management decisions and inaccurate conclusions regarding patient adherence for iron chelation therapy. Because of that, monitoring patients' body iron burden by MRI measured liver iron concentration has been the standard of care in iron overloaded patients.
“In our Radiology department we are using FerriSmart for measurement of liver iron concentration. The set up and acquisition of the images for FerriSmart is easy. We upload the images to the system and receive the report immediately. It is quite practical. Previously we had a manual measurement programme and measurement of each patient took approximately 10-15 minutes which was a great workload for us. FerriSmart has increased our productivity, we can reach more thalassemia patients now.”
“FerriSmart is easy to use, just upload data then wait a few second for the result. Access to the result is simple, with quick service support.”